Description

2-(4-Nitrophenyl)Acetyl Chloride is a versatile and highly reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its ability to efficiently introduce the 2-(4-nitrophenyl)acetyl moiety, a key functional group for constructing complex molecules with specific electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require high-purity intermediates for developing active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting specific enzyme inhibition or receptor modulation.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and plant growth regulators where the nitrophenyl group contributes to biological activity.
• Peptide Mimetics & Conjugation: Employed as an acylating agent for modifying amino acids or peptides to create novel peptide mimetics or drug conjugates.
• Dye & Pigment Manufacturing: Acts as an intermediate in the synthesis of complex azo dyes and organic pigments, leveraging the nitro group for color development.
• Polymer Chemistry: Serves as a monomer or cross-linking agent in the production of specialty polymers with tailored thermal or optical properties.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D for exploring new organic reactions and synthesizing novel chemical entities.

Basic Information

Product Name	2-(4-Nitrophenyl)Acetyl Chloride
CAS No.	50434-36-1
Molecular Formula	C8H6ClNO3
Molecular Weight	199.59 g/mol
Synonyms	4-Nitrophenacyl Chloride; 2-(4-Nitrophenyl)-2-oxoethyl Chloride; (4-Nitrophenyl)glyoxyloyl Chloride; 4-Nitro-ω-chloroacetophenone; α-Chloro-4-nitroacetophenone; p-Nitrophenacyl Chloride; 2-Oxo-2-(4-nitrophenyl)ethyl Chloride; 1-Chloro-2-(4-nitrophenyl)ethanone
EINECS	Contact for details

Quality Control

Every batch of 2-(4-Nitrophenyl)Acetyl Chloride is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards through rigorous analytical protocols, including HPLC, GC, NMR, and FTIR, to verify identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	White to pale yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.