Description

(-)-Colletol CAS NO 50376-40-4 is a specific enantiomer of the natural product colletol, a compound of significant interest in advanced organic synthesis and pharmaceutical research. This chiral building block is valued for its unique stereochemistry, which is critical for imparting specific biological activity and directing stereoselective reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for the synthesis of complex molecules, novel drug candidates, and specialty materials.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of new active pharmaceutical ingredients (APIs), particularly in oncology and antiviral therapeutic areas.
• Asymmetric Synthesis: Employed as a sophisticated chiral auxiliary or starting material in stereocontrolled organic reactions to construct complex molecular architectures.
• Natural Product Synthesis: Used in the total or semi-synthesis of complex natural products and their analogs for biological evaluation.
• Agrochemical Research: Serves as a precursor in the development of novel, enantiomerically pure pesticides and herbicides with enhanced efficacy and environmental profiles.
• Material Science: Potential application in the synthesis of chiral ligands for catalysis or advanced polymeric materials with specific optical properties.

Basic Information

Product Name	(-)-Colletol
CAS No.	50376-40-4
Molecular Formula	C15H26O2
Molecular Weight	238.37 g/mol
Synonyms	(-)-Colletol; (3R,4aR,5S,6R,8aR)-5-(1-Hydroxy-1-methylethyl)-3,4a,5,6,7,8,8a,9-octahydro-6-methylnaphtho[2,3-b]furan-2(1H)-one; Colletol; (3R,4aR,5S,6R,8aR)-5-(2-Hydroxypropan-2-yl)-6-methyl-1,2,3,4,4a,5,6,8a-octahydronaphtho[2,3-b]furan-2-one; (3R,4aR,5S,6R,8aR)-5-(1-Hydroxy-1-methylethyl)-3,4a,5,6,7,8,8a,9-octahydro-6-methyl-1H-naphtho[2,3-b]furan-2-one
EINECS	Contact for details

Quality Control

Our (-)-Colletol is produced under strict quality management systems to ensure batch-to-batch consistency and high enantiomeric purity, which is critical for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.