Description

3-Isopropyl-6-(2-Methyl-Propyl)-2,5-Piperazinedione is a specialized diketopiperazine (DKP) derivative, a class of cyclic dipeptides known for their diverse biological activities and utility as chiral building blocks. This compound matters as a high-purity synthetic intermediate, offering a rigid, constrained scaffold for advanced pharmaceutical research and fine chemical synthesis. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and the synthesis of complex organic molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of potential active pharmaceutical ingredients (APIs), particularly for protease inhibitors and other biologically active compounds.
• Peptidomimetic Research: Used as a constrained scaffold in medicinal chemistry to develop novel peptidomimetics with improved metabolic stability and bioavailability.
• Agrochemical Synthesis: Acts as an intermediate in the development of advanced crop protection agents and pesticides.
• Ligand and Catalyst Development: Utilized in the preparation of chiral ligands for asymmetric catalysis and organometallic complexes.
• Bioconjugation and Linker Chemistry: Its functional groups make it suitable for creating specialized linkers in bioconjugation and prodrug strategies.
• Reference Standard: Supplied as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	3-Isopropyl-6-(2-Methyl-Propyl)-2,5-Piperazinedione
CAS No.	5625-50-3
Molecular Formula	C11H20N2O2
Molecular Weight	212.29 g/mol
Synonyms	3-Isopropyl-6-isobutylpiperazine-2,5-dione; 3-Isopropyl-6-(2-methylpropyl)-2,5-piperazinedione; 3-Isopropyl-6-isobutyl-2,5-diketopiperazine; Cyclo(L-valyl-L-leucyl); Cyclo(Val-Leu); Cyclo(V-L); Diketopiperazine (Val-Leu); L-Valyl-L-leucine anhydride
EINECS	Contact for details

Quality Control

Our 3-Isopropyl-6-(2-Methyl-Propyl)-2,5-Piperazinedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material is suitable for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. Recommended long-term storage at 2-8°C. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.