Description

(3S)-3-((4-Hydroxyphenyl)Methyl)-2,5-Piperazinedione CAS NO 5625-49-0 is a chiral piperazinedione derivative, a high-purity synthetic intermediate of significant interest in advanced organic synthesis. Its value lies in its unique molecular scaffold, which serves as a critical building block for constructing complex pharmacologically active molecules. This compound is essential for research and development chemists in the pharmaceutical and fine chemical industries, particularly those focused on developing novel therapeutic agents and chiral catalysts.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets.
• Peptidomimetic Research: Serves as a constrained dipeptide analog for designing and synthesizing novel peptidomimetics with enhanced metabolic stability and bioavailability.
• Asymmetric Catalyst Ligand Precursor: Used in the development of chiral ligands for asymmetric catalysis, enabling the synthesis of enantiomerically pure compounds.
• Chemical Biology Probe Development: Employed in the creation of molecular probes to study enzyme mechanisms and protein-protein interactions.
• Academic & Institutional Research: A valuable compound for fundamental studies in organic chemistry, medicinal chemistry, and stereochemistry at universities and R&D institutes.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis organizations (CSOs) and CDMOs producing specialized compounds for client projects.

Basic Information

Product Name	(3S)-3-((4-Hydroxyphenyl)Methyl)-2,5-Piperazinedione
CAS No.	5625-49-0
Molecular Formula	C11H12N2O3
Molecular Weight	220.23 g/mol
Synonyms	(3S)-3-(4-Hydroxybenzyl)piperazine-2,5-dione; L-3-(4-Hydroxybenzyl)-2,5-diketopiperazine; (S)-3-(4-Hydroxybenzyl)-2,5-piperazinedione; (S)-3-(p-Hydroxybenzyl)-2,5-diketopiperazine; (S)-3-(4-Hydroxybenzyl)piperazine-2,5-dione; Cyclo(L-tyrosylglycine); L-Tyr-Gly 2,5-diketopiperazine; DKP-Tyr
EINECS	Contact for details

Quality Control

Our (3S)-3-((4-Hydroxyphenyl)Methyl)-2,5-Piperazinedione is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for research and pharmaceutical development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.