Description

3,6-Bis(Hydroxymethyl)-2,5-Piperazinedione is a versatile heterocyclic organic compound featuring a piperazinedione core with hydroxymethyl substituents. This unique structure makes it a valuable intermediate for the synthesis of more complex molecules, particularly in pharmaceutical research and fine chemical manufacturing. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications in drug discovery and material science.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly those containing piperazine or diketopiperazine motifs.
• Peptidomimetic Research: Serves as a core scaffold in the development of peptidomimetics and constrained peptides for drug discovery programs.
• Polymer Chemistry: Used as a monomer or cross-linking agent in the production of specialty polymers, such as polyamides or polyurethanes, due to its dual hydroxyl functionality.
• Agrochemical Synthesis: An intermediate in the manufacture of certain herbicides, fungicides, and plant growth regulators.
• Ligand and Chelator Precursor: The structure can be modified to create novel ligands for metal catalysis or chelating agents.
• Academic & Industrial R&D: Employed in chemical biology and medicinal chemistry research for library synthesis and structure-activity relationship (SAR) studies.

Basic Information

Product Name	3,6-Bis(Hydroxymethyl)-2,5-Piperazinedione
CAS No.	5625-41-2
Molecular Formula	C6H10N2O4
Molecular Weight	174.16 g/mol
Synonyms	2,5-Diketo-3,6-bis(hydroxymethyl)piperazine; 3,6-Bis(hydroxymethyl)-2,5-diketopiperazine; 3,6-Di(hydroxymethyl)-2,5-piperazinedione; 2,5-Piperazinedione, 3,6-bis(hydroxymethyl)-; Bis(hydroxymethyl)diketopiperazine; DHDK; Contact for additional synonyms.
EINECS	227-058-4

Quality Control

Our 3,6-Bis(Hydroxymethyl)-2,5-Piperazinedione is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) documenting identity, purity, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which can affect product stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.