Description

Diethyl Piperazine-1,4-Dicarboxylate is a versatile and high-purity chemical intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for constructing complex molecular architectures, particularly those containing the piperazine pharmacophore. This compound is essential for research and development chemists and process engineers in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-quality intermediates for API development and fine chemical manufacturing.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system, antimicrobials, and other therapeutic agents containing piperazine or morpholine-like structures.
• Agrochemical Synthesis: Used in the development and production of advanced pesticides, herbicides, and fungicides where the piperazine moiety contributes to biological activity.
• Ligand and Catalyst Preparation: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Polymer Chemistry: Acts as a monomer or chain extender in the production of specialty polymers, such as polyamides and polyurethanes, imparting specific thermal or mechanical properties.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating novel compound libraries for screening.
• Fine Chemical Production: Integral to the multi-step synthesis of complex fine chemicals and dyes that require a protected piperazine derivative.

Basic Information

Product Name	Diethyl Piperazine-1,4-Dicarboxylate
CAS No.	5470-28-0
Molecular Formula	C10H18N2O4
Molecular Weight	230.26 g/mol
Synonyms	1,4-Piperazinedicarboxylic acid, diethyl ester; Diethyl 1,4-piperazinedicarboxylate; Diethyl piperazine-1,4-dicarboxylate; Ethyl piperazine-1,4-dicarboxylate; NSC 403697; Piperazine-1,4-dicarboxylic acid diethyl ester; 1,4-Di(ethoxycarbonyl)piperazine; Diethyl piperazine-dicarboxylate
EINECS	226-787-9

Quality Control

Our Diethyl Piperazine-1,4-Dicarboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets the highest standards of purity and consistency required for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, identity, and impurity profiles. Our quality commitment aligns with cGMP principles where applicable, ensuring reliable supply for critical development and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.