Description

9-cis-Retinoic Acid is a biologically active geometric isomer of retinoic acid, a key signaling molecule derived from Vitamin A. This compound is of significant interest due to its distinct binding affinity and activity profile compared to all-trans-retinoic acid, making it a crucial tool for research and development. It is primarily sought after by the pharmaceutical, biotechnology, and advanced life science research sectors for its role in cellular differentiation, gene regulation, and as a reference standard.

Application

• Pharmaceutical R&D: Investigated as a potential therapeutic agent or prodrug in oncology and dermatology.
• Biochemical Research: Used as a selective ligand to study retinoid receptor (RXR) signaling pathways and nuclear receptor function.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in HPLC and LC-MS assays.
• Cell Culture & Differentiation Studies: Applied in *in vitro* models to induce and study cellular differentiation, particularly in stem cell research.
• Metabolic Pathway Analysis: Utilized to explore the biosynthesis and interconversion of Vitamin A derivatives.

Basic Information

Product Name	9-cis-Retinoic Acid
CAS No.	5300-03-8
Molecular Formula	C₂₀H₂₈O₂
Molecular Weight	300.44 g/mol
Synonyms	9-cis-Retinoic Acid; Alitretinoin; 9Z-Retinoic Acid; Panretin; (2E,4E,6Z,8E)-3,7-Dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic Acid; LGD1057; 9-cis-RA
EINECS	226-161-5

Quality Control

Our 9-cis-Retinoic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure it meets the stringent requirements for research and development applications. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Allow the sealed container to reach room temperature before opening to prevent condensation. Keep away from oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (IR)	Spectrum matches reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
All-trans-Retinoic Acid	≤ 1.0%
Solubility	Soluble in DMSO, ethanol; practically insoluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.