Description

2-Thiophenecarbonyl Chloride is a versatile and highly reactive organosulfur compound, serving as a critical acylating agent and synthetic building block. Its value lies in its ability to efficiently introduce the 2-thiophenecarbonyl moiety into target molecules, enabling the synthesis of complex heterocyclic systems. This reagent is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries who require high-purity intermediates for advanced chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) with thiophene-based scaffolds, including potential candidates for central nervous system (CNS) and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the production of advanced pesticides, herbicides, and fungicides where the thiophene ring contributes to biological activity and selectivity.
• Polymer and Material Science: Acts as a monomer or modifying agent in the creation of conductive polymers, organic semiconductors, and specialty materials with tailored electronic properties.
• Ligand and Catalyst Preparation: Employed in the synthesis of novel ligands for metal-organic frameworks (MOFs) and catalysts used in cross-coupling reactions.
• Dye and Pigment Manufacturing: Serves as a precursor for the development of organic dyes and pigments with specific colorfastness and light-absorption characteristics.
• Research & Development: A fundamental reagent in organic chemistry laboratories for method development and the exploration of new chemical entities in medicinal and synthetic chemistry.

Basic Information

Product Name	2-Thiophenecarbonyl Chloride
CAS No.	5271-67-0
Molecular Formula	C5H3ClOS
Molecular Weight	146.59 g/mol
Synonyms	2-Thenoyl Chloride; Thiophene-2-carbonyl Chloride; 2-Thiophenecarboxylic Acid Chloride; α-Thenoyl Chloride; 2-Carboxythiophene Chloride; Thenoyl Chloride; Thiophene-2-Carboxylic Acid Chloride; 2-Thienylcarbonyl Chloride
EINECS	226-085-9

Quality Control

Our 2-Thiophenecarbonyl Chloride is manufactured under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity assays and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay purity, appearance, and moisture content. We are committed to consistent quality and supply chain reliability for our global B2B partners.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases, alcohols, and amines. Recommended storage temperature is 2-8°C for long-term stability. The product is moisture-sensitive; keep container tightly sealed under an inert atmosphere (e.g., nitrogen) to prevent hydrolysis.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.