Description

Bis(Trimethylsilyl)Estradiol is a silylated derivative of the natural estrogen hormone, 17β-estradiol, designed to enhance stability and handling properties for advanced chemical synthesis. This compound is crucial for researchers and manufacturers requiring a protected form of estradiol to prevent unwanted reactions at the phenolic hydroxyl group during complex organic transformations. It serves as a key protected intermediate in the pharmaceutical industry for the development of steroidal drugs, hormone analogs, and other high-value fine chemicals.

Application

• Pharmaceutical Intermediate: A critical protected building block in the multi-step synthesis of novel steroidal therapeutics and hormone replacement therapies.
• Research Chemical: Used in academic and industrial R&D for studying estrogen receptor activity, metabolic pathways, and developing new bioassays.
• Derivatization Agent: Employed in analytical chemistry to create volatile, thermally stable derivatives of estrogens for precise analysis via GC-MS or LC-MS.
• Fine Chemical Synthesis: Serves as a precursor in the production of specialized estradiol analogs, labeled compounds, and other high-purity steroid derivatives.
• Process Chemistry: Utilized in pilot-scale and commercial manufacturing where the trimethylsilyl (TMS) protecting group is essential for specific reaction steps.

Basic Information

Product Name	Bis(Trimethylsilyl)Estradiol
CAS No.	5150-62-9
Molecular Formula	C24H40O2Si2
Molecular Weight	416.75 g/mol
Synonyms	Estradiol 3,17-bis(trimethylsilyl) ether; 17β-Estradiol bis(trimethylsilyl) ether; 3,17β-Bis(trimethylsiloxy)estra-1,3,5(10)-triene; O3,O17-Bis(trimethylsilyl)estradiol; TMS-Estradiol; Bistrimethylsilylestradiol; E2-bis-TMS; NSC 163079
EINECS	225-904-7

Quality Control

Our Bis(Trimethylsilyl)Estradiol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediates and research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, assay, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.