Description

Menadiol Diacetate is a synthetic, fat-soluble vitamin K derivative, also known as vitamin K4 diacetate. This compound serves as a stable, bioavailable precursor to menadione (vitamin K3), playing a crucial role in the synthesis of prothrombin and other blood clotting factors. It is essential for manufacturers in the pharmaceutical, nutraceutical, and animal feed industries requiring a reliable source of vitamin K activity for formulations targeting coagulation disorders and nutritional supplementation.

Application

• Pharmaceutical Intermediates: Key starting material or active pharmaceutical ingredient (API) in the synthesis of hemostatic agents and vitamin K supplements.
• Nutraceuticals & Dietary Supplements: Incorporated into vitamin complexes and specialized nutritional formulas to support bone health and blood coagulation.
• Animal Feed & Veterinary Medicine: Used as a vitamin K fortifier in premixes to prevent hemorrhagic conditions in livestock and poultry.
• Biochemical Research: Employed as a standard or reagent in studies related to vitamin K metabolism, coagulation pathways, and enzyme function.
• Cosmeceuticals: Potential ingredient in topical formulations aimed at reducing dark circles or skin bruising due to its role in vascular health.

Basic Information

Product Name	Menadiol Diacetate
CAS No.	573-20-6
Molecular Formula	C15H14O4
Molecular Weight	258.27 g/mol
Synonyms	Vitamin K4 Diacetate; Menadiol Diacetate; 2-Methyl-1,4-naphthalenediol Diacetate; 1,4-Diacetoxy-2-methylnaphthalene; Acetomenaphthone; Kappaxin; Kayvite; Vitamin K4; Menadiol acetate ester; 2-Methyl-1,4-naphthohydroquinone diacetate
EINECS	209-354-1

Quality Control

Our Menadiol Diacetate is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for assay and purity, to ensure it meets stringent specifications for pharmaceutical and nutritional use. Certificates of Analysis (COA) documenting identity, purity, and related substances are provided with every shipment. We adhere to cGMP principles where applicable, and our quality systems support compliance with major pharmacopoeial standards (USP/EP) upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere); therefore, containers should be kept tightly sealed under an inert gas (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0%
Melting Point	112°C - 116°C
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.