Description

Ethionamide is a synthetic thiocarbamide derivative with potent bacteriostatic activity against *Mycobacterium tuberculosis*. This compound is critical for global public health initiatives, providing a key therapeutic option in multi-drug resistant (MDR-TB) and extensively drug-resistant (XDR-TB) tuberculosis treatment regimens. It is primarily required by pharmaceutical manufacturers, research institutions, and compounding facilities engaged in the development and production of anti-tuberculosis medications.

Application

• Active Pharmaceutical Ingredient (API) in second-line anti-tuberculosis drugs.
• Critical component in combination therapy for multi-drug resistant tuberculosis (MDR-TB).
• Research chemical for studying mycobacterial metabolism and drug resistance mechanisms.
• Reference standard in analytical laboratories for quality control of pharmaceutical formulations.
• Intermediate in the synthesis of novel thiocarbamide derivatives for antimicrobial research.
• Used in pharmacological studies to investigate its pharmacokinetics and pharmacodynamics.

Basic Information

Product Name	Ethionamide
CAS No.	536-33-4
Molecular Formula	C8H10N2S
Molecular Weight	166.24 g/mol
Synonyms	2-Ethylisonicotinothioamide; 2-Ethyl-4-pyridinecarbothioamide; α-Ethylisonicotinthioamide; Ethioniamide; Trecator; 1314 Th; Amidazine; Iridocin; 2-Ethylpyridine-4-carbothioamide; Nicotithioamide; 2-Ethylisonicotinic acid thioamide
EINECS	208-635-8

Quality Control

Our Ethionamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. We provide full traceability and Certificates of Analysis (COA) confirming identity, purity, and the absence of specified impurities, aligning with ICH guidelines and current pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and potency. Store away from incompatible materials.

Specification

Item	Specification
Appearance	Yellow to pale yellow crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	NMT 0.5%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm
Related Substances (HPLC)	Total impurities NMT 1.0% Any individual impurity NMT 0.5%
Microbial Limits	Conforms to EP/USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.