Description

Diosmin CAS NO 520-27-4 is a purified flavonoid glycoside, a bioactive compound derived from natural sources. It is valued for its potent venotonic and vascular-protective properties, making it a critical active pharmaceutical ingredient (API) in the formulation of vascular health supplements and pharmaceutical products. This high-purity ingredient is essential for manufacturers in the pharmaceutical, nutraceutical, and cosmeceutical industries seeking to develop evidence-based formulations for circulatory support.

Application

• Pharmaceutical API: Primary active ingredient in prescription and OTC medications for chronic venous insufficiency (CVI), hemorrhoids, and varicose veins.
• Dietary Supplements: Key component in capsules, tablets, and powders targeting vascular health, capillary fragility, and lymphatic drainage.
• Cosmeceutical Formulations: Used in creams, serums, and gels for its anti-inflammatory and capillary-strengthening benefits, helping to reduce dark circles and puffiness.
• Veterinary Medicine: Incorporated into animal health products for managing circulatory issues in companion animals and livestock.
• Functional Food & Beverages: Potential fortification agent in health-focused food and drink products designed to support microcirculation.
• Research & Development: Serves as a reference standard and key material in pharmacological and biochemical research on flavonoid activity.

Basic Information

Product Name	Diosmin
CAS No.	520-27-4
Molecular Formula	C28H32O15
Molecular Weight	608.54 g/mol
Synonyms	3',5,7-Trihydroxy-4'-methoxyflavone 7-rutinoside; Barosmin; Daflon (component); Diosmetin 7-O-rutinoside; Diosmine; Venosmine; 7-[[6-O-(6-Deoxy-α-L-mannopyranosyl)-β-D-glucopyranosyl]oxy]-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one
EINECS	208-289-7

Quality Control

Our Diosmin is manufactured under strict quality management systems. It is produced to meet high-purity standards suitable for pharmaceutical applications, with typical specifications aligning with major pharmacopoeial monographs. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure traceability and compliance with relevant regulatory frameworks, including cGMP where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	Light yellow to yellow powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Conforms to standard
Assay (HPLC)	≥ 90.0% - 102.0% (on dried basis)
Loss on Drying	≤ 5.0%
Sulfated Ash	≤ 0.5%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH Q3C
Microbial Limits	Complies with Ph. Eur. / USP

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.