Description

Tolazoline Hydrochloride CAS NO 59-97-2 is a pharmaceutical-grade active pharmaceutical ingredient (API) and a potent α-adrenergic receptor antagonist. This compound is critical for its vasodilatory properties, making it a key intermediate in the synthesis of specialized cardiovascular and diagnostic agents. It is primarily utilized by pharmaceutical manufacturers, research institutions, and fine chemical producers engaged in developing treatments for conditions like pulmonary hypertension and peripheral vascular disorders.

Application

• Pharmaceutical API: Primary use as an active ingredient in formulations for vasodilatory medications.
• Veterinary Medicine: Used in treatments for pulmonary hypertension in animals, particularly in equine medicine.
• Diagnostic Agent: Employed in pharmacological testing and diagnostic procedures to assess peripheral circulation.
• Chemical Intermediate: Serves as a key building block in the synthesis of more complex adrenergic compounds.
• Research & Development: Essential for pharmacological studies targeting α-adrenergic receptors in academic and industrial labs.
• Reference Standard: Used in quality control laboratories as a high-purity standard for HPLC and other analytical methods.

Basic Information

Product Name	Tolazoline Hydrochloride
CAS No.	59-97-2
Molecular Formula	C10H12N2·HCl
Molecular Weight	196.68 g/mol
Synonyms	2-Benzyl-2-imidazoline hydrochloride; Priscoline Hydrochloride; Benzazoline Hydrochloride; Tolazolinium Chloride; 2-(Benzyl)-4,5-dihydro-1H-imidazole hydrochloride; 2-Benzyl-4,5-dihydro-1H-imidazole monohydrochloride; CAS 59-97-2
EINECS	200-447-5

Quality Control

Our Tolazoline Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets stringent specifications for identity, purity, and potency, aligning with ICH guidelines. A comprehensive Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and microbiological limits is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Heavy Metals	≤ 20 ppm
Microbiological Enumeration	Meets Ph. Eur. 2.6.12 / USP <61>

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.