Description

Isoniazid CAS NO 54-85-3 is a first-line synthetic antimicrobial agent and a cornerstone of modern tuberculosis (TB) chemotherapy. Its primary value lies in its potent and selective bactericidal activity against *Mycobacterium tuberculosis*, making it critical for global public health initiatives. This essential pharmaceutical active ingredient is primarily required by manufacturers of anti-tuberculosis drugs for the formulation of tablets, capsules, and combination therapies, as well as by research institutions developing new therapeutic regimens.

Application

• First-line Anti-tuberculosis Drug Formulation: Primary active pharmaceutical ingredient (API) in combination therapies for treating active and latent tuberculosis infections.
• Pharmaceutical Intermediates: Used in the synthesis of derivative compounds and prodrugs to enhance efficacy or reduce side effects.
• Veterinary Medicine: Employed in the treatment of tuberculosis in animals, particularly in livestock and zoo settings.
• Clinical & Diagnostic Research: Serves as a critical reagent in microbiological laboratories for drug susceptibility testing of TB strains.
• Preventive Therapy: Key component in chemoprophylaxis for individuals at high risk of developing active TB.
• Academic & Pharmaceutical R&D: Used as a reference standard and building block in medicinal chemistry research for novel antimicrobial agents.

Basic Information

Product Name	Isoniazid
CAS No.	54-85-3
Molecular Formula	C6H7N3O
Molecular Weight	137.14 g/mol
Synonyms	Isonicotinic acid hydrazide; INH; Isonicotinyl hydrazide; 4-Pyridinecarboxylic acid hydrazide; Rimifon; Tubazid; Laniazid; Nydrazid; Isozid; Hydrazid kyseliny isonikotinove; Isoniazida; Isoniazidum
EINECS	200-214-6

Quality Control

Our Isoniazid is manufactured under strict quality management systems, with grades available to meet USP, EP, BP, and IP pharmacopoeial standards. Every batch undergoes comprehensive analytical testing including identification, assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) detailing all test results is provided with each shipment to ensure full traceability and compliance with cGMP guidelines for pharmaceutical ingredients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which can affect stability and potency. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White or almost white, crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.5% - 101.0% (on anhydrous basis)
Water (Karl Fischer)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%
Microbial Enumeration	Meets EP/USP requirements

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.