Description

2-Piperazineacetic Acid, 5-(2-Aminoethyl)-3,6-Dioxo-, (2S,5S)- (9Ci) is a high-purity, stereochemically defined chiral building block of significant interest in advanced pharmaceutical research and development. Its complex molecular architecture, featuring a piperazine core with acetic acid and aminoethyl-dioxo substituents, makes it a valuable intermediate for constructing sophisticated active pharmaceutical ingredients (APIs). This compound is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical and biotechnology sectors for the synthesis of novel therapeutic agents, particularly those targeting the central nervous system and other complex disease pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, including potential protease inhibitors and neuroactive compounds.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to explore new chemical entities for therapeutic applications.
• Peptidomimetic Development: Serves as a constrained scaffold for designing and synthesizing peptidomimetics, which mimic peptides but with enhanced metabolic stability.
• Chemical Biology Probes: Employed in the creation of specialized molecular probes to study enzyme function and biological pathways.
• Process Chemistry & Scale-Up: Investigated for use in developing robust, scalable synthetic routes for potential commercial API manufacturing.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, advanced intermediates.

Basic Information

Product Name	2-Piperazineacetic Acid, 5-(2-Aminoethyl)-3,6-Dioxo-, (2S,5S)- (9Ci)
CAS No.	499774-99-1
Molecular Formula	C8H15N3O4
Molecular Weight	217.22 g/mol
Synonyms	(2S,5S)-5-(2-Aminoethyl)-3,6-dioxopiperazine-2-acetic acid; (2S,5S)-2-(5-(2-Aminoethyl)-3,6-dioxopiperazin-2-yl)acetic acid; 2-Piperazineacetic acid, 5-(2-aminoethyl)-3,6-dioxo-, (2S,5S)-; (S,S)-5-(2-Aminoethyl)-3,6-dioxopiperazine-2-acetic acid; L,L-5-(2-Aminoethyl)-3,6-dioxopiperazine-2-acetic acid; A chiral diketopiperazine acetic acid derivative; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Every batch of 2-Piperazineacetic Acid, 5-(2-Aminoethyl)-3,6-Dioxo-, (2S,5S)- (9Ci) is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and stereochemical integrity, which are critical for sensitive pharmaceutical R&D applications. Certificates of Analysis (COA) detailing specifications such as chiral purity (HPLC), assay, and impurity profiles are available for each lot. Our quality commitment aligns with the standards expected for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% (2S,5S)-isomer
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.