Description

Pemaglitazar is a potent and selective dual peroxisome proliferator-activated receptor (PPAR) α/γ agonist, a class of compounds designed for metabolic regulation. This high-purity pharmaceutical intermediate is critical for research and development in advanced metabolic disease therapeutics. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing next-generation treatments for conditions like type 2 diabetes and dyslipidemia.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel dual PPAR agonist drug candidates.
• Metabolic Disease Research: Used in preclinical and clinical research to study mechanisms of insulin sensitization and lipid metabolism.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in API manufacturing.
• Biochemical Tool Compound: Employed in vitro and in vivo studies to investigate PPAR receptor pharmacology and signaling pathways.
• Drug Discovery Programs: Integral component in medicinal chemistry efforts aimed at optimizing glitazar-class therapeutics.

Basic Information

Product Name	Pemaglitazar
CAS No.	496050-39-6
Molecular Formula	C₁₉H₂₀N₂O₅S
Molecular Weight	388.44 g/mol
Synonyms	Pemaglitazar; (S)-2-Ethoxy-3-[4-[2-(4-methanesulfonyloxyphenyl)ethoxy]phenyl]propanoic acid; DRF 10945; DRF-10945; DRF10945; (αS)-2-Ethoxy-3-[4-[2-[4-[(methylsulfonyl)oxy]phenyl]ethoxy]phenyl]propanoic acid; (S)-2-Ethoxy-3-(4-{2-[4-(methylsulfonyloxy)phenyl]ethoxy}phenyl)propionic acid
EINECS	Contact for details

Quality Control

Our Pemaglitazar is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by advanced chromatographic methods (HPLC). We adhere to cGMP principles where applicable to support our clients' regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.