Description

4-Trifluoromethyl-Piperidine-1,4-Dicarboxylic Acid Mono-tert-Butyl Ester is a high-value, multi-functional piperidine derivative that serves as a critical advanced intermediate in modern synthetic chemistry. Its core value lies in the strategic combination of a protected carboxylic acid group and a trifluoromethyl-substituted piperidine ring, enabling efficient construction of complex pharmacophores. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries who require sophisticated building blocks for drug discovery and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting the central nervous system (CNS), metabolic disorders, and infectious diseases.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Medicinal Chemistry & Drug Discovery: Employed in lead optimization and scaffold hopping to introduce the piperidine moiety and modulate physicochemical properties like lipophilicity and bioavailability.
• Chemical Biology Probe Development: Serves as a precursor for creating labeled compounds or affinity probes to study enzyme mechanisms and protein-ligand interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and non-commercial research quantities.
• Academic & Institutional Research: Utilized in university and government laboratories for methodological studies in organic synthesis and fluorine chemistry.

Basic Information

Product Name	4-Trifluoromethyl-Piperidine-1,4-Dicarboxylic Acid Mono-tert-Butyl Ester
CAS No.	495415-51-5
Molecular Formula	C12H18F3NO4
Molecular Weight	297.27 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-4-(trifluoromethyl)piperidine-4-carboxylic acid; 4-Carboxy-4-(trifluoromethyl)piperidine-1-carboxylic acid tert-butyl ester; 4-(Trifluoromethyl)piperidine-1,4-dicarboxylic acid 1-tert-butyl ester; 4-Trifluoromethyl-1,4-piperidinedicarboxylic acid mono-tert-butyl ester; 1-Boc-4-(trifluoromethyl)piperidine-4-carboxylic acid; 4-(Trifluoromethyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester, 4-carboxy-; tert-Butyl 4-carboxy-4-(trifluoromethyl)piperidine-1-carboxylate
EINECS	Contact for details

Quality Control

Every batch of 4-Trifluoromethyl-Piperidine-1,4-Dicarboxylic Acid Mono-tert-Butyl Ester is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our products are characterized using advanced techniques including NMR (¹H, ¹³C, ¹⁹F), HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.