Description

1,4-Piperidinedicarboxylic Acid, 4-(Cyanomethyl)-, 1-(1,1-Dimethylethyl) 4-Ethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its piperidine-dicarboxylate core functionalized with a cyanomethyl group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and other therapeutic agents.

Application

• Pharmaceutical Intermediate: A key synthon in the multi-step synthesis of novel drug candidates, especially those targeting neurological receptors.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Custom Synthesis: Serves as a starting material or intermediate for contract research and manufacturing organizations (CROs/CMOs) producing bespoke compounds.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant and commercial production.
• Chemical Biology Probes: Can be utilized to create labeled or tagged molecules for studying biological pathways and target engagement.

Basic Information

Product Name	1,4-Piperidinedicarboxylic Acid, 4-(Cyanomethyl)-, 1-(1,1-Dimethylethyl) 4-Ethyl Ester
CAS No.	495414-81-8
Molecular Formula	C15H24N2O4
Molecular Weight	296.36 g/mol
Synonyms	4-(Cyanomethyl)-1,4-piperidinedicarboxylic acid 1-tert-butyl 4-ethyl ester; 1-(tert-Butyl) 4-ethyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate; tert-Butyl ethyl 4-(cyanomethyl)piperidine-1,4-dicarboxylate; 4-Cyanomethyl-piperidine-1,4-dicarboxylic acid 1-tert-butyl ester 4-ethyl ester; 495414-81-8; 1,4-Piperidinedicarboxylic acid, 4-(cyanomethyl)-, 1-(1,1-dimethylethyl) 4-ethyl ester
EINECS	Contact for details

Quality Control

Our 1,4-Piperidinedicarboxylic Acid, 4-(Cyanomethyl)-, 1-(1,1-Dimethylethyl) 4-Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D and production. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. For long-term storage, consider inert atmosphere conditions to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single impurity	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.