Description

4-(2-Bromo-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate crucial for the synthesis of complex active pharmaceutical ingredients (APIs). This compound serves as a key building block in medicinal chemistry, enabling the introduction of a functionalized piperazine moiety into target molecules. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics, particularly within central nervous system (CNS) and oncology research pipelines.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry research and development.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs), especially those containing a piperazine core structure.
• CNS Drug Development: Serves as a precursor in the research and production of potential therapeutics targeting neurological and psychiatric disorders.
• Oncological Research: Employed in the creation of experimental compounds for cancer treatment research due to its versatile chemical functionality.
• Chemical Biology & Proteomics: Utilized as a scaffold or linker in the design of chemical probes for studying biological systems and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	4-(2-Bromo-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	494773-35-2
Molecular Formula	C15H21BrN2O2
Molecular Weight	341.25 g/mol
Synonyms	tert-Butyl 4-(2-bromophenyl)piperazine-1-carboxylate; 1-Boc-4-(2-bromophenyl)piperazine; 4-(2-Bromophenyl)-1-(tert-butoxycarbonyl)piperazine; 1-(tert-Butoxycarbonyl)-4-(2-bromophenyl)piperazine; N-Boc-4-(2-bromophenyl)piperazine; 4-(2-Bromophenyl)piperazine-1-carboxylic acid tert-butyl ester; 2-Bromophenylpiperazine Boc derivative; Boc-2-BrPP
EINECS	Contact for details

Quality Control

Our 4-(2-Bromo-Phenyl)-Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring the material meets the stringent requirements for pharmaceutical R&D and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.