Description

1-(4-Trifluoromethoxy-Phenyl)-Piperazine Hydrochloride is a high-purity, synthetically versatile organic building block and pharmaceutical intermediate. This compound is valued for its trifluoromethoxy-substituted aromatic piperazine structure, which is crucial for modulating the physicochemical and biological properties of target molecules. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential central nervous system (CNS) agents, including antidepressants, antipsychotics, and anxiolytics.
• Agrochemical Research: Used in the development of novel pesticides and herbicides, where the trifluoromethoxy group can enhance biological activity and metabolic stability.
• Chemical Biology Probe: Serves as a scaffold for creating molecular probes to study receptor-ligand interactions, particularly involving serotonin and dopamine receptor systems.
• Custom Synthesis & Contract Manufacturing: Employed by fine chemical suppliers for the custom synthesis of complex molecules for client-specific research programs.
• Academic & Institutional Research: Utilized in university and government laboratories for fundamental research in medicinal chemistry and organic synthesis methodologies.

Basic Information

Product Name	1-(4-Trifluoromethoxy-Phenyl)-Piperazine Hydrochloride
CAS No.	490030-46-1
Molecular Formula	C11H14ClF3N2O
Molecular Weight	282.69 g/mol
Synonyms	1-[4-(Trifluoromethoxy)phenyl]piperazine hydrochloride; 4-(Trifluoromethoxy)phenylpiperazine hydrochloride; 1-(4-(Trifluoromethoxyphenyl))piperazine HCl; 4-(Piperazin-1-yl)phenyl trifluoromethyl ether hydrochloride; TFMPP hydrochloride (context-specific); p-Trifluoromethoxyphenylpiperazine hydrochloride
EINECS	Contact for details

Quality Control

Our 1-(4-Trifluoromethoxy-Phenyl)-Piperazine Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports applications in GMP and non-GMP research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed immediately after use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.