Description

Ethyl 4-[2-(3-Chlorophenyl)-2-Hydroxyethyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is a high-value, synthetically versatile chiral intermediate with a complex molecular architecture. Its structure, featuring a tetrahydro-1(2H)-pyrazinecarboxylate core linked to a substituted phenyl ethanol moiety, makes it a critical building block for advanced pharmaceutical synthesis. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries, particularly for creating novel active pharmaceutical ingredients (APIs) with targeted biological activity.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the multi-step synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders.
• API Development: Used in research and process chemistry for constructing the core scaffold of potential new therapeutic agents.
• Asymmetric Synthesis: Employed as a precursor or reagent in stereoselective chemical transformations due to its defined chiral centers.
• Medicinal Chemistry Research: Provides a versatile template for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Fine Chemical Production: Utilized in the custom synthesis of specialty chemicals and advanced materials requiring high-purity, complex organic molecules.
• Contract Manufacturing (CMO/CDMO): A critical raw material for contract research and manufacturing organizations producing bespoke compounds for clients.

Basic Information

Product Name	Ethyl 4-[2-(3-Chlorophenyl)-2-Hydroxyethyl]Tetrahydro-1(2H)-Pyrazinecarboxylate
CAS No.	486439-08-1
Molecular Formula	C15H21ClN2O3
Molecular Weight	312.79 g/mol
Synonyms	Ethyl 4-[2-(3-chlorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate; 1-Carbethoxy-4-[2-(3-chlorophenyl)-2-hydroxyethyl]piperazine; 4-[2-(3-Chlorophenyl)-2-hydroxyethyl]-1-piperazinecarboxylic acid ethyl ester; (RS)-Ethyl 4-[2-(3-chlorophenyl)-2-hydroxyethyl]piperazine-1-carboxylate; 1-Piperazinecarboxylic acid, 4-[2-(3-chlorophenyl)-2-hydroxyethyl]-, ethyl ester; Ethyl 4-(2-(3-chlorophenyl)-2-hydroxyethyl)piperazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 4-[2-(3-Chlorophenyl)-2-Hydroxyethyl]Tetrahydro-1(2H)-Pyrazinecarboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the exacting standards required for pharmaceutical R&D and production. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profiles is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (or as specified)
Related Substances (HPLC)	Individual impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.