Description

Azd-2858 CAS NO 486424-20-8 is a potent and selective small molecule inhibitor primarily targeting the GSK-3β and Aurora kinase pathways. This compound is of significant value in pharmaceutical research and development for its role in modulating key cellular processes involved in proliferation and disease. It is an essential research chemical for scientists in oncology, neurology, and regenerative medicine, facilitating the study of novel therapeutic mechanisms.

Application

• Oncology Research: Used as a key biochemical tool to investigate the role of GSK-3β and Aurora kinases in cancer cell signaling, proliferation, and apoptosis.
• Neurodegenerative Disease Studies: Employed in preclinical research for conditions like Alzheimer's disease, exploring pathways related to tau phosphorylation and neuronal survival.
• Stem Cell & Regenerative Medicine: Applied in studies to understand and control stem cell differentiation and self-renewal by modulating Wnt/β-catenin signaling.
• Biochemical Assay Development: Serves as a reference standard and active control in high-throughput screening (HTS) and kinase profiling assays.
• Academic & Pharmaceutical R&D: A critical reagent for target validation and lead optimization phases in drug discovery pipelines.

Basic Information

Product Name	Azd-2858
CAS No.	486424-20-8
Molecular Formula	C₂₀H₂₀N₈O
Molecular Weight	388.42 g/mol
Synonyms	AZD-2858; AZD2858; 8-(4-Methylpiperazin-1-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazine; GSK-3β Inhibitor (AZD-2858); Aurora Kinase Inhibitor; 3-(1H-Pyrazol-4-yl)-8-(4-methyl-1-piperazinyl)imidazo[1,2-a]pyrazine
EINECS	Contact for details

Quality Control

Our Azd-2858 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, mass spectrometry (MS) for identity confirmation, and NMR for structural verification. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research-grade standards and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC-MS)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.