Description

Denagliptin is a potent and selective dipeptidyl peptidase-4 (DPP-4) inhibitor, a class of compounds widely recognized for their therapeutic potential in managing type 2 diabetes. Its high selectivity and efficacy make it a valuable active pharmaceutical ingredient (API) and a critical reference standard for research and development. This compound is essential for pharmaceutical manufacturers, research institutions, and analytical laboratories focused on metabolic disease therapeutics and drug discovery.

Application

• Primary Active Pharmaceutical Ingredient (API) in the formulation of anti-diabetic medications.
• Reference Standard for analytical method development and validation in quality control laboratories.
• Key intermediate in the research and synthesis of novel DPP-4 inhibitor analogs.
• Biochemical research tool for studying the role of DPP-4 in glucose metabolism and related pathways.
• Pharmacological studies investigating mechanisms of action and efficacy in preclinical models.
• Impurity standard for monitoring and controlling the quality of related pharmaceutical products.

Basic Information

Product Name	Denagliptin
CAS No.	483369-58-0
Molecular Formula	C₁₉H₂₃N₅O₃
Molecular Weight	369.42 g/mol
Synonyms	Denagliptin; GSK-823093; 2-[[6-(3-Amino-1-piperidinyl)-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-4-fluorobenzonitrile; (2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine (Note: This IUPAC name may refer to a closely related structure; the most common synonym is Denagliptin).
EINECS	Contact for details

Quality Control

Our Denagliptin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identification by spectroscopic methods, to ensure it meets high-grade pharmaceutical standards. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.