Description

4-Chloro-2-Methylphenylmagnesium Bromide is a highly reactive Grignard reagent, a critical organometallic intermediate for constructing complex molecular architectures. Its value lies in enabling efficient carbon-carbon bond formation, a cornerstone reaction in fine chemical and pharmaceutical synthesis. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries who require a reliable, high-purity building block for introducing the 4-chloro-2-methylphenyl moiety.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those requiring a halogenated aromatic scaffold.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where the chloromethylphenyl group imparts specific biological activity.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized phosphine or N-heterocyclic carbene (NHC) ligands used in asymmetric catalysis.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as hole-transport layers or monomers for conductive polymers.
• Cross-Coupling Reactions: A vital reagent in Kumada, Negishi, and other transition-metal-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Addition Reactions: Used to add the 4-chloro-2-methylphenyl group to carbonyl compounds (aldehydes, ketones, esters) to form secondary or tertiary alcohols.

Basic Information

Item	Details
Product Name	4-Chloro-2-Methylphenylmagnesium Bromide
CAS No.	480438-47-9
Molecular Formula	C7H6BrClMg
Molecular Weight	229.78 g/mol
Synonyms	(4-Chloro-2-methylphenyl)magnesium bromide; 2-Methyl-4-chlorophenylmagnesium bromide; 4-Chloro-o-tolylmagnesium bromide; Grignard reagent, (4-chloro-2-methylphenyl)magnesium bromide; Magnesium, bromo(4-chloro-2-methylphenyl)-; (4-Chloro-2-methylphenyl)magnesium bromide solution
EINECS	Contact for details

Quality Control

Every batch of our 4-Chloro-2-Methylphenylmagnesium Bromide is manufactured and handled under stringent inert atmosphere conditions to ensure reactivity and purity. We provide comprehensive Certificates of Analysis (COA) detailing concentration (typically supplied as a solution in THF or diethyl ether), titration assay, and impurity profile. Our quality systems are designed to support cGMP and ISO standards for advanced synthetic intermediates.

Storage

Preserve in a tightly closed container, protected from light. This material is hygroscopic (moisture-sensitive) and must be stored under an inert atmosphere (argon or nitrogen) at 2-8°C. For solutions, store in Sure/Seal® or similar reagent bottles. Keep away from moisture, heat, and oxidizing agents.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light brown solution
Concentration	0.5 M in THF or as specified
Assay (Titration)	≥ 95%
Identity (IR/NMR)	Conforms to structure

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.