Description

(4-(1-Piperidinylmethyl)Phenyl)Magnesium Bromide is a highly reactive organomagnesium reagent, specifically an aryl Grignard reagent, essential for advanced organic synthesis. Its core value lies in enabling the efficient formation of carbon-carbon bonds, a fundamental step in constructing complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for introducing the (4-(1-piperidinylmethyl)phenyl) moiety into target molecules during the development of new drug candidates.
• Agrochemical Production: Used in the synthesis of advanced herbicides, fungicides, and insecticides that require specific aryl-piperidine structural motifs.
• Ligand and Catalyst Development: Serves as a building block for creating novel ligands and organometallic catalysts used in asymmetric synthesis and polymerization processes.
• Material Science Research: Employed in the synthesis of organic semiconductors, liquid crystals, and other functional organic materials requiring precise aryl group incorporation.
• Cross-Coupling Reactions: Acts as a nucleophilic coupling partner in reactions such as Kumada coupling with various palladium or nickel catalysts.
• Nucleophilic Addition to Carbonyls: Used for the addition to aldehydes, ketones, esters, and other electrophiles to form new alcohols and carboxylic acid derivatives.

Basic Information

Item	Detail
Product Name	(4-(1-Piperidinylmethyl)Phenyl)Magnesium Bromide
CAS No.	480424-83-7
Molecular Formula	C12H16BrMgN
Molecular Weight	278.47 g/mol (as bromide salt)
Synonyms	(4-(Piperidin-1-ylmethyl)phenyl)magnesium bromide; 1-[(4-Bromophenyl)methyl]piperidine, Grignard reagent; 4-(Piperidin-1-ylmethyl)phenylmagnesium bromide; p-(Piperidinomethyl)phenylmagnesium bromide; (4-Piperidin-1-ylmethyl-phenyl)-magnesium bromide; Grignard Reagent of 1-[(4-Bromophenyl)methyl]piperidine; Aryl Grignard Reagent CAS 480424-83-7
EINECS	Contact for details

Quality Control

Every batch of our (4-(1-Piperidinylmethyl)Phenyl)Magnesium Bromide is manufactured and handled under strict inert atmosphere conditions to ensure reactivity and purity. We employ rigorous analytical protocols, including titration (Karl Fischer, GC, HPLC) and spectroscopic methods (NMR), to verify concentration, identity, and the absence of significant protic impurities. A comprehensive Certificate of Analysis (COA) detailing batch-specific results is provided with each shipment to guarantee consistency and support your quality assurance processes.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly volatile, hygroscopic, and easily oxidized nature, this reagent must be stored under a dry, inert atmosphere (argon or nitrogen) at 2-8°C. The container should be kept in a cool, dry, well-ventilated area away from moisture, heat, and sources of ignition. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Clear, colorless to light yellow solution
Concentration (in THF or Ether)	0.5 M - 1.0 M (Custom concentrations available)
Assay (by Titration)	≥ 95% (as Grignard reagent)
Identification (IR / NMR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.