Description

4-(4-Carboxybenzyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine core and a carboxylic acid functional group. This compound is critical for medicinal chemists as it provides a versatile and reactive scaffold for the synthesis of complex molecules, particularly in the development of new therapeutic agents. It is primarily utilized by research institutions and pharmaceutical companies engaged in the discovery and process development of novel drugs, especially those targeting central nervous system (CNS) disorders and other areas requiring sophisticated heterocyclic chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing a piperazine moiety.
• Medicinal Chemistry Research: Used extensively in research and development (R&D) for structure-activity relationship (SAR) studies and lead optimization.
• Protease Inhibitor Synthesis: Serves as a precursor in the construction of molecules designed to inhibit specific enzymes, such as proteases involved in disease pathways.
• CNS Drug Development: Applied in the synthesis of potential therapeutics for neurological and psychiatric conditions, where piperazine derivatives are common.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP conditions.
• Chemical Biology Probes: Utilized in the creation of chemical probes for studying biological targets and pathways in academic and industrial research.

Basic Information

Product Name	4-(4-Carboxybenzyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester
CAS No.	479353-63-4
Molecular Formula	C18H26N2O4
Molecular Weight	334.41 g/mol
Synonyms	1-Boc-4-(4-Carboxybenzyl)piperazine; tert-Butyl 4-(4-carboxybenzyl)piperazine-1-carboxylate; 4-[(1-Boc-4-piperazinyl)methyl]benzoic Acid; 4-(4-Carboxybenzyl)-1-piperazinecarboxylic Acid 1,1-Dimethylethyl Ester; 4-[(4-(tert-Butoxycarbonyl)piperazin-1-yl)methyl]benzoic Acid; Piperazine-1-carboxylic acid, 4-[(4-carboxyphenyl)methyl]-, 1,1-dimethylethyl ester; Boc-4-(4-Carboxybenzyl)piperazine
EINECS	Contact for details

Quality Control

Our 4-(4-Carboxybenzyl)Piperazine-1-Carboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. For projects requiring regulatory support, we can supply material manufactured in compliance with ICH Q7 guidelines and support drug master file (DMF) submissions.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.