Description

tert-Butyl 4-(5-formylpyrid-2-yl)piperazine-1-carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its piperazine core and formylpyridine moiety. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) and oncology targets. It is essential for research and development chemists and process scale-up teams in the pharmaceutical and biotechnology industries seeking reliable, high-quality intermediates for novel drug discovery and development programs.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules, particularly those targeting neurological disorders and cancer.
• API Synthesis: Used as a versatile building block for constructing the core scaffold of various active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Enables the exploration of structure-activity relationships (SAR) in drug discovery programs due to its reactive aldehyde and protected amine functionalities.
• Process Chemistry & Scale-Up: Serves as a critical material for process optimization and the commercial-scale manufacturing of target drug substances.
• Bioconjugation & Probe Development: The formyl group allows for site-specific conjugation, useful in creating biochemical probes or antibody-drug conjugates (ADCs).

Basic Information

Product Name	tert-Butyl 4-(5-Formylpyrid-2-yl)piperazine-1-carboxylate
CAS No.	479226-10-3
Molecular Formula	C15H21N3O3
Molecular Weight	291.35 g/mol
Synonyms	1-Boc-4-(5-formyl-2-pyridyl)piperazine; tert-Butyl 4-(5-formyl-2-pyridinyl)-1-piperazinecarboxylate; 2-(4-Boc-piperazin-1-yl)-5-formylpyridine; 1-(tert-Butoxycarbonyl)-4-(5-formylpyridin-2-yl)piperazine; 4-(5-Formyl-2-pyridyl)-1-piperazinecarboxylic acid tert-butyl ester; BOC-4-(5-FORMYL-2-PYRIDYL)PIPERAZINE; 479226-10-3
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-(5-formylpyrid-2-yl)piperazine-1-carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.