Description

[4-(Piperazine-1-Carbonyl)-Phenyl]-Carbamic Acid tert-Butyl Ester is a high-purity, advanced pharmaceutical intermediate with the CAS number 478798-20-8. This compound is a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and oncological pathways. It is essential for research and development chemists, process scale-up engineers, and manufacturers in the global pharmaceutical and biotechnology sectors who require reliable, high-quality intermediates for drug discovery and production.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors and receptor modulators.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a versatile linker component connecting E3 ligase ligands to target protein binders.
• Peptidomimetic Synthesis: Used in the construction of peptide-like molecules with enhanced stability and bioavailability for therapeutic applications.
• Chemical Biology Research: Employed as a tool compound for studying protein-protein interactions and cellular signaling pathways.
• Custom Synthesis & Contract Manufacturing: Supplied for bespoke synthesis projects requiring a protected piperazine-carbonyl aniline derivative.
• Scale-Up and Process Chemistry: Utilized in the optimization and kilogram-scale production of target molecules for clinical trials.

Basic Information

Product Name	[4-(Piperazine-1-Carbonyl)-Phenyl]-Carbamic Acid tert-Butyl Ester
CAS No.	478798-20-8
Molecular Formula	C16H23N3O3
Molecular Weight	305.37 g/mol
Synonyms	tert-Butyl N-[4-(piperazine-1-carbonyl)phenyl]carbamate; 1-[(4-{[(tert-Butoxy)carbonyl]amino}phenyl)carbonyl]piperazine; BOC-Piperazine-1-Carboxylic Acid (4-Aminophenyl)amide; 4-(Piperazine-1-carbonyl)aniline, N-BOC protected; 4-(N-Boc-amino)benzoic acid piperazide; N-Boc-4-(piperazine-1-carbonyl)aniline; 478798-20-8
EINECS	Contact for details

Quality Control

Our [4-(Piperazine-1-Carbonyl)-Phenyl]-Carbamic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, confirming compliance with customer specifications and supporting regulatory filings for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is moisture-sensitive; keep the container tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.