Description

(2S)-2-(Fmoc-Amino)Tetradecanoic Acid CAS NO 478706-50-2 is a high-purity, chiral building block specifically engineered for advanced peptide synthesis and pharmaceutical research. This compound is critical for the controlled introduction of a long-chain fatty acid moiety with an Fmoc-protected amino group, enabling the synthesis of complex, lipopeptide-based molecules. It is an essential raw material for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors who require precise stereochemistry and reliable quality for developing novel therapeutics and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the stepwise construction of lipopeptides and modified peptides, particularly where a C14 fatty acid chain is required.
• Pharmaceutical Intermediate: Used in the research and development of novel drug candidates, including antimicrobial peptides, hormone analogs, and targeted delivery conjugates.
• Bioconjugation: Serves as a linker or modifying agent for the lipidation of proteins, antibodies, or other biomolecules to alter their pharmacokinetic properties.
• Combinatorial Chemistry: Employed in libraries for drug discovery to explore structure-activity relationships (SAR) of peptide-based compounds.
• Academic & Institutional Research: A vital tool for studying peptide structure, function, and the impact of lipidation on bioactivity and membrane interaction.
• Production of Custom Peptides: Used by CROs and CDMOs for the GMP or non-GMP synthesis of client-specific peptide sequences for preclinical and clinical studies.

Basic Information

Product Name	(2S)-2-(Fmoc-Amino)Tetradecanoic Acid
CAS No.	478706-50-2
Molecular Formula	C29H39NO4
Molecular Weight	465.63 g/mol
Synonyms	Fmoc-L-Aminotetradecanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-2-aminotetradecanoic Acid; N-α-Fmoc-L-2-aminomyristic Acid; (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)tetradecanoic Acid; Fmoc-Ahx(13)-OH (contextual); Fmoc-14-Amino-myristic Acid; Nα-Fmoc-L-2-Aminotetradecanoic Acid
EINECS	Contact for details

Quality Control

Every batch of (2S)-2-(Fmoc-Amino)Tetradecanoic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and chiral integrity meet the exacting standards required for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, chiral purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.