Description

8H-Pyrido[1,2-A]Pyrrolo[2,1-C]Pyrazine,8-Ethyl-5,6,9,10,11,11A-Hexahydro-,(8R,11As)-Rel-(9Ci) is a high-purity, complex heterocyclic organic compound with the CAS number 478552-94-2, serving as a critical chiral building block in advanced pharmaceutical synthesis. Its intricate fused-ring structure and defined stereochemistry make it an invaluable intermediate for developing novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. This compound is essential for medicinal chemists and process development scientists in pharmaceutical R&D and fine chemical manufacturing seeking to introduce specific molecular complexity into their synthetic pathways.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel therapeutic agents.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Process Chemistry: Serves as a defined starting material or intermediate in the scale-up synthesis of complex target molecules.
• Asymmetric Synthesis: Utilized in reactions requiring specific stereochemical control due to its defined (8R,11As) configuration.
• Library Synthesis: Employed in the generation of diverse compound libraries for high-throughput screening in drug discovery.
• Fine Chemical Production: An important building block for the custom synthesis of specialty chemicals and advanced materials.

Basic Information

Item	Detail
Product Name	8H-Pyrido[1,2-A]Pyrrolo[2,1-C]Pyrazine,8-Ethyl-5,6,9,10,11,11A-Hexahydro-,(8R,11As)-Rel-(9Ci)
CAS No.	478552-94-2
Molecular Formula	C14H20N2
Molecular Weight	216.33 g/mol
Synonyms	(8R,11aS)-8-Ethyl-5,6,9,10,11,11a-hexahydro-8H-pyrido[1,2-a]pyrrolo[2,1-c]pyrazine; rel-(8R,11aS)-8-Ethyl-5,6,9,10,11,11a-hexahydro-8H-pyrido[1,2-a]pyrrolo[2,1-c]pyrazine; 8H-Pyrido[1,2-a]pyrrolo[2,1-c]pyrazine, 8-ethyl-5,6,9,10,11,11a-hexahydro-, (8R,11aS)-rel-; 478552-94-2; SCHEMBL218830; AOB67717; (rel)-(8R,11aS)-8-Ethyl-5,6,9,10,11,11a-hexahydro-8H-pyrido[1,2-a]pyrrolo[2,1-c]pyrazine
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Every batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry to confirm identity, purity, and chiral integrity. Certificates of Analysis (COA) detailing all specifications are available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory requirements in pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a cool, dry, and well-ventilated area. Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere to ensure stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.