Description

1-[(4-Methylphenyl)Sulfonyl]-4-[3-(Trifluoromethyl)-2-Pyridinyl]Piperazine is a high-purity, advanced pharmaceutical intermediate characterized by its unique sulfonyl and trifluoromethyl-substituted heterocyclic structure. This compound is of significant commercial value for its role in the synthesis of novel active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for building complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, especially for neurological and psychiatric disorders.
• Chemical Synthesis Scaffold: Used in medicinal chemistry for structure-activity relationship (SAR) studies due to its piperazine core and electron-withdrawing groups.
• API Development: Serves as a critical precursor in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) targeting specific receptors.
• Biochemical Research: Employed in academic and industrial laboratories as a tool compound for probing biological pathways and enzyme inhibition.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for client-specific projects requiring complex heterocyclic chemistry.

Basic Information

Product Name	1-[(4-Methylphenyl)Sulfonyl]-4-[3-(Trifluoromethyl)-2-Pyridinyl]Piperazine
CAS No.	478077-40-6
Molecular Formula	C17H18F3N3O2S
Molecular Weight	385.40 g/mol
Synonyms	4-[3-(Trifluoromethyl)pyridin-2-yl]-1-(4-methylphenyl)sulfonylpiperazine; 1-(4-Methylbenzenesulfonyl)-4-[3-(trifluoromethyl)pyridin-2-yl]piperazine; 1-Tosyl-4-[3-(trifluoromethyl)-2-pyridyl]piperazine; 1-(p-Tolylsulfonyl)-4-[3-(trifluoromethyl)-2-pyridinyl]piperazine; 478077-40-6; 4-(3-(Trifluoromethyl)pyridin-2-yl)-1-tosylpiperazine
EINECS	Contact for details

Quality Control

Our 1-[(4-Methylphenyl)Sulfonyl]-4-[3-(Trifluoromethyl)-2-Pyridinyl]Piperazine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the stringent requirements for pharmaceutical R&D. A detailed Certificate of Analysis (COA) is provided with each shipment, guaranteeing traceability and consistent high purity.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect this light-sensitive material from moisture and contamination.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Individual impurity ≤ 0.5%
Total Impurities	≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.