Description

4-(4-Benzyl-Piperazin-1-Yl)-1,1,1-Trifluoro-But-3-En-2-One is a high-value trifluoromethylated enone building block featuring a benzylpiperazine moiety. This compound is strategically important for medicinal chemistry research and the development of novel active pharmaceutical ingredients (APIs), particularly due to its role as a key intermediate in synthesizing molecules with enhanced metabolic stability and bioavailability. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced material sectors.

Application

• Pharmaceutical Intermediate: Serves as a critical synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the trifluoromethyl group and a basic amine functionality.
• Agrochemical Synthesis: Acts as a building block for creating novel pesticides and herbicides with improved efficacy and environmental profiles.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and biological pathways.
• Advanced Material Precursor: Potential use in synthesizing specialty polymers or organic electronic materials due to its unique electronic properties.
• Custom Synthesis & Contract Manufacturing: A key starting material for custom synthesis projects and scale-up processes under cGMP or ISO standards.

Basic Information

Item	Details
Product Name	4-(4-Benzyl-Piperazin-1-Yl)-1,1,1-Trifluoro-But-3-En-2-One
CAS No.	478047-08-4
Molecular Formula	C15H17F3N2O
Molecular Weight	298.31 g/mol
Synonyms	1,1,1-Trifluoro-4-(4-benzyl-1-piperazinyl)-3-buten-2-one; 4-(4-Benzylpiperazin-1-yl)-1,1,1-trifluorobut-3-en-2-one; 1-[4-(Benzyl)piperazino]-4,4,4-trifluoro-2-buten-1-one; 4,4,4-Trifluoro-1-(4-benzyl-1-piperazinyl)-2-buten-1-one; BTFB; (E)-4-(4-Benzylpiperazin-1-yl)-1,1,1-trifluorobut-3-en-2-one; Trifluoromethyl vinyl ketone benzylpiperazine derivative
EINECS	Contact for details

Quality Control

Our production of 4-(4-Benzyl-Piperazin-1-Yl)-1,1,1-Trifluoro-But-3-En-2-One adheres to stringent internal quality standards to ensure batch-to-batch consistency and reliability for research and development. Each lot is characterized by modern analytical techniques including HPLC, GC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.