Description

4-(4-[(4-Methylphenyl)Sulfonyl]Piperazino)Benzenecarbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a benzonitrile core linked to a piperazine-sulfonyl-toluene moiety. This compound is valued for its role as a critical building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is essential for research and development chemists in the pharmaceutical and agrochemical industries seeking to develop new therapeutic agents or crop protection products.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its versatile chemical scaffold.
• Agrochemical Development: Serves as a building block for creating new active ingredients in pesticides and herbicides.
• Chemical Synthesis: Employed in organic synthesis for constructing complex heterocyclic compounds and functional materials.
• Academic & Contract Research: Utilized in university and CRO (Contract Research Organization) laboratories for exploratory research and custom synthesis projects.

Basic Information

Product Name	4-(4-[(4-Methylphenyl)Sulfonyl]Piperazino)Benzenecarbonitrile
CAS No.	478046-94-5
Molecular Formula	C19H21N3O2S
Molecular Weight	355.46 g/mol
Synonyms	4-[4-(4-Methylphenyl)sulfonylpiperazin-1-yl]benzonitrile; 4-[4-(p-Tolylsulfonyl)piperazin-1-yl]benzonitrile; 4-(4-(p-Toluenesulfonyl)piperazino)benzonitrile; 4-(4-(4-Methylphenylsulfonyl)piperazino)benzonitrile; 4-(4-Tosylpiperazin-1-yl)benzonitrile; 1-(4-Cyanophenyl)-4-(p-tolylsulfonyl)piperazine; 478046-94-5; 4-(4-(4-Methylphenyl)sulfonylpiperazin-1-yl)benzonitrile
EINECS	Contact for details

Quality Control

Our 4-(4-[(4-Methylphenyl)Sulfonyl]Piperazino)Benzenecarbonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, related substances, and residual solvents. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.