Description

1,1,1-Trifluoro-4-[4-(2-Hydroxy-Ethyl)-Piperazin-1-Yl]-But-3-En-2-One is a high-value trifluoromethylated enone building block featuring a piperazine moiety, designed for advanced synthetic chemistry. This compound is critical for medicinal chemistry research and development, enabling the efficient synthesis of complex molecules with potential biological activity. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers for creating novel drug candidates and high-performance materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to introduce the trifluoromethyl group and a basic nitrogen center, which can improve metabolic stability, membrane permeability, and target binding affinity.
• Fluorinated Compound Library Synthesis: Serves as a versatile precursor for generating diverse libraries of fluorinated compounds for high-throughput screening (HTS) in drug discovery programs.
• Agrochemical Development: Employed in the research and synthesis of novel herbicides, fungicides, and insecticides, where the fluorine atoms can enhance biological activity and environmental stability.
• Material Science Precursor: Potential use in the development of advanced polymers, liquid crystals, or organic electronic materials that benefit from fluorinated components.
• Chemical Biology Probe Synthesis: Useful for creating molecular probes to study enzyme function or protein-protein interactions within biological systems.

Basic Information

Product Name	1,1,1-Trifluoro-4-[4-(2-Hydroxy-Ethyl)-Piperazin-1-Yl]-But-3-En-2-One
CAS No.	478040-79-8
Molecular Formula	C10H13F3N2O2
Molecular Weight	250.22 g/mol
Synonyms	4-(4-(2-Hydroxyethyl)piperazin-1-yl)-1,1,1-trifluorobut-3-en-2-one; 1,1,1-Trifluoro-4-(4-(2-hydroxyethyl)piperazin-1-yl)but-3-en-2-one; 1-[4-(2-Hydroxyethyl)-1-piperazinyl]-4,4,4-trifluoro-2-buten-1-one; 4,4,4-Trifluoro-1-[4-(2-hydroxyethyl)-1-piperazinyl]-2-buten-1-one; (E/Z)-1,1,1-Trifluoro-4-[4-(2-hydroxyethyl)piperazin-1-yl]but-3-en-2-one; Trifluoromethyl enone piperazine derivative
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-4-[4-(2-Hydroxy-Ethyl)-Piperazin-1-Yl]-But-3-En-2-One is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent chemical identity. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ISO 9001 standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.