Description

Threo-Pentonoyl Chloride, 2,5-Anhydro-3,4-Dideoxy-3-Methyl- (9Ci) is a specialized carbohydrate-derived acid chloride, a high-purity building block critical for advanced synthetic chemistry. Its value lies in enabling the precise introduction of a functionalized pentose moiety under mild conditions, facilitating the synthesis of complex molecules with high stereochemical control. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries developing novel nucleoside analogs, enzyme inhibitors, and other bioactive compounds.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel nucleoside and nucleotide analogs with potential antiviral or anticancer activity.
• Agrochemical Synthesis: Used in constructing complex sugar-based active ingredients for next-generation herbicides or fungicides.
• Bioconjugation & Probe Development: Serves as a reactive handle for labeling biomolecules (e.g., proteins, peptides) or creating diagnostic probes due to its acyl chloride functionality.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for creating specialty polymers with unique degradation profiles or bio-interactive properties.
• Academic & Process R&D: Employed in methodological studies and scale-up process development for stereoselective glycosylation and acylation reactions.
• Carbohydrate Chemistry: Fundamental building block for the preparation of modified sugars, deoxy-sugars, and complex oligosaccharide mimetics.

Basic Information

Product Name	Threo-Pentonoyl Chloride, 2,5-Anhydro-3,4-Dideoxy-3-Methyl- (9Ci)
CAS No.	477938-21-9
Molecular Formula	C6H9ClO2
Molecular Weight	148.59 g/mol
Synonyms	2,5-Anhydro-3,4-dideoxy-3-methyl-D-threo-pentonoyl chloride; 3,4-Dideoxy-3-methyl-D-threo-pentono-1,5-lactone chloride; Methyl-deoxy-threo-pentonoyl chloride; (3R,4S)-3,4-Dideoxy-3-methylpentono-1,5-lactone chloride; Threo-3,4-dideoxy-3-methylpentonoyl chloride; D-threo-Pentonoyl chloride, 2,5-anhydro-3,4-dideoxy-3-methyl-; 477938-21-9; 2,5-Anhydro-3,4-dideoxy-3-methyl-threo-pentonic acid chloride
EINECS	Contact for details

Quality Control

Every batch of Threo-Pentonoyl Chloride is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring traceability and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at temperatures between 2°C and 8°C (refrigerated) for optimal stability. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from strong bases, oxidizers, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.