Description

1-[1,1'-Biphenyl]-4-Yl-3-[4-(4-Methoxyphenyl)Piperazino]-1-Propanone is a high-purity, advanced pharmaceutical intermediate characterized by its complex biphenyl and piperazine-based structure. This compound is critical for research and development in medicinal chemistry, particularly in the synthesis of novel therapeutic agents targeting central nervous system and other disorders. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers seeking reliable, high-quality building blocks for complex synthesis pathways.

Application

• Pharmaceutical Intermediate: A key building block in the research and synthesis of new chemical entities (NCEs) and active pharmaceutical ingredients (APIs), particularly for CNS-targeting drugs.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its modifiable piperazine and biphenyl moieties.
• Biochemical Tool Compound: Serves as a precursor or reference standard in the development of assays for receptor binding studies and pharmacological profiling.
• Fine Chemical Synthesis: Employed in multi-step organic synthesis for creating complex molecules with potential biological activity in academic and industrial settings.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	1-[1,1'-Biphenyl]-4-Yl-3-[4-(4-Methoxyphenyl)Piperazino]-1-Propanone
CAS No.	477328-91-9
Molecular Formula	C26H28N2O2
Molecular Weight	400.52 g/mol
Synonyms	1-(Biphenyl-4-yl)-3-[4-(4-methoxyphenyl)piperazin-1-yl]propan-1-one; 3-[4-(4-Methoxyphenyl)-1-piperazinyl]-1-(4-phenylphenyl)-1-propanone; 1-(4-Biphenylyl)-3-[4-(4-methoxyphenyl)-1-piperazinyl]-1-propanone; Biphenyl-4-yl(3-(4-(4-methoxyphenyl)piperazin-1-yl)propyl)methanone; CAS 477328-91-9
EINECS	Contact for details

Quality Control

Our 1-[1,1'-Biphenyl]-4-Yl-3-[4-(4-Methoxyphenyl)Piperazino]-1-Propanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical research. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment. We support development under various quality frameworks, including research-grade and cGMP for advanced applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.