Description

5-Chloro-2-Iodo-3-Methoxy-Pyrazine is a halogenated pyrazine derivative, a versatile and highly functionalized heterocyclic building block. Its unique substitution pattern makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. This compound is particularly valuable for pharmaceutical chemists and agrochemical researchers seeking to introduce specific halogen and methoxy functionalities into pyrazine-based scaffolds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in medicinal chemistry programs targeting kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where the pyrazine core provides specific biological activity.
• Material Science Research: Serves as a precursor for the synthesis of organic electronic materials, ligands for catalysis, and other functional organic compounds.
• Chemical Biology & Proteomics: Employed as a building block for creating molecular probes, tags, and linkers used in studying biological systems and drug-target interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes.

Basic Information

Product Name	5-Chloro-2-Iodo-3-Methoxy-Pyrazine
CAS No.	476623-12-8
Molecular Formula	C5H4ClIN2O
Molecular Weight	270.45 g/mol
Synonyms	3-Methoxy-5-chloro-2-iodopyrazine; 2-Iodo-5-chloro-3-methoxypyrazine; 5-Chloro-3-methoxy-2-iodopyrazine; Pyrazine, 5-chloro-2-iodo-3-methoxy-; 476623-12-8; 5-Chloro-2-iodo-3-methoxypyrazine
EINECS	Contact for details

Quality Control

Every batch of 5-Chloro-2-Iodo-3-Methoxy-Pyrazine is produced and analyzed under strict quality management protocols. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (typically by HPLC), identity confirmation (by NMR and/or IR), and levels of specific impurities. Our quality systems are designed to support cGMP and ISO standards for research and development use, ensuring traceability and consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry, and well-ventilated place. Recommended long-term storage temperature is 2-8°C. Allow the sealed container to reach ambient temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Related Substances (HPLC)	Individual impurity ≤1.0%
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.