Description

5-Bromo-2-Iodo-3-Methoxypyrazine is a high-purity, multi-halogenated pyrazine derivative serving as a critical building block in advanced organic synthesis. Its unique halogen substitution pattern makes it a valuable scaffold for constructing complex heterocyclic compounds, particularly in pharmaceutical and agrochemical research. This intermediate is essential for medicinal chemists and R&D professionals developing novel active ingredients, where precise molecular architecture is paramount for achieving desired biological activity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially in kinase inhibitor and antiviral research programs.
• Agrochemical Synthesis: Building block for developing new generation herbicides and fungicides with specific modes of action.
• Material Science Research: Used in the creation of organic electronic materials and liquid crystals due to its halogenated aromatic structure.
• Cross-Coupling Reactions: Serves as a versatile substrate for Suzuki, Stille, and Negishi cross-coupling reactions to form complex biaryl systems.
• Ligand and Catalyst Development: Foundation for synthesizing specialized nitrogen-containing ligands for transition metal catalysis.
• Chemical Biology Probes: Utilized in the design of molecular probes and tags for studying biological systems.

Basic Information

Product Name	5-Bromo-2-Iodo-3-Methoxypyrazine
CAS No.	476622-89-6
Molecular Formula	C5H4BrIN2O
Molecular Weight	314.91 g/mol
Synonyms	3-Methoxy-5-bromo-2-iodopyrazine; 2-Iodo-5-bromo-3-methoxypyrazine; 5-Bromo-2-iodo-3-methoxy-pyrazine; Pyrazine, 5-bromo-2-iodo-3-methoxy-; 476622-89-6; 5-Br-2-I-3-MeO-Pyrazine
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-2-Iodo-3-Methoxypyrazine is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. We guarantee high chemical purity and lot-to-lot consistency to support your critical research and development. A detailed Certificate of Analysis (COA) providing results for identity, purity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. The compound is light-sensitive (store away from light).

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.