Description

4-(S)-Hydroxy-2-Piperidinone is a chiral piperidinone derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its stereochemical purity and functional group versatility, enabling the construction of complex molecular architectures. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of piperidine-based drug candidates, including potential central nervous system (CNS) agents and enzyme inhibitors.
• Agrochemical Research: Used in the development of novel pesticides and herbicides where the piperidinone scaffold imparts specific biological activity.
• Asymmetric Synthesis: Employed as a chiral auxiliary or starting material in stereoselective reactions to introduce the (S)-configured hydroxy group.
• Fine Chemical Production: Serves as a precursor for manufacturing specialty chemicals, flavors, and fragrances requiring high enantiomeric purity.
• Academic & R&D: A valuable reagent for methodological studies in organic chemistry and medicinal chemistry research programs.

Basic Information

Product Name	4-(S)-Hydroxy-2-Piperidinone
CAS No.	476014-92-3
Molecular Formula	C5H9NO2
Molecular Weight	115.13 g/mol
Synonyms	(4S)-4-Hydroxypiperidin-2-one; (S)-4-Hydroxy-2-piperidinone; 4-Hydroxy-2-piperidinone, (S)-; 2-Piperidinone, 4-hydroxy-, (4S)-; (S)-4-Hydroxy-2-piperidone; (4S)-4-Hydroxy-2-piperidone; 4-Hydroxy-2-piperidone, (S)-
EINECS	Contact for details

Quality Control

Our 4-(S)-Hydroxy-2-Piperidinone is produced under strict quality management protocols to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized using advanced analytical techniques including chiral HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment, supporting cGMP and ISO standards for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.