Description

Aleglitazar CAS NO 475479-34-6 is a high-purity, small-molecule pharmaceutical compound belonging to the glitazar class. It is a potent dual agonist of the peroxisome proliferator-activated receptors (PPAR) alpha and gamma, making it a critical intermediate and reference standard in metabolic disease research. This compound is essential for pharmaceutical R&D teams, academic researchers, and contract manufacturing organizations (CMOs) focused on developing novel therapeutics for type 2 diabetes and dyslipidemia.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for analytical method development, validation, and quality control in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a key synthetic building block in the production of investigational new drugs targeting metabolic syndromes.
• Biochemical Research: Employed in in vitro and in vivo studies to investigate PPAR receptor pharmacology, signaling pathways, and mechanisms of action.
• Preclinical Development: Utilized in animal model studies for evaluating the efficacy, pharmacokinetics, and safety profiles of glitazar-based therapies.
• Process Chemistry & Scale-up: Acts as a benchmark for optimizing synthetic routes and purification processes during pilot and commercial-scale production.

Basic Information

Product Name	Aleglitazar
CAS No.	475479-34-6
Molecular Formula	C20H20N2O5S
Molecular Weight	400.45 g/mol
Synonyms	5-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]-2-methoxy-N-[[4-(trifluoromethyl)phenyl]methyl]benzamide; GFT505; R-1439; R1439; (R)-5-((2,4-Dioxothiazolidin-5-yl)methyl)-2-methoxy-N-((4-(trifluoromethyl)phenyl)methyl)benzamide; 5-[(2,4-Dioxo-1,3-thiazolidin-5-yl)methyl]-2-methoxy-N-{[4-(trifluoromethyl)phenyl]methyl}benzamide
EINECS	Contact for details

Quality Control

Our Aleglitazar is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, residual solvent analysis, and identity confirmation via IR and MS, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting regulatory submissions and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept in a desiccated environment to prevent moisture absorption, which can affect stability and purity. For long-term storage, consider inert gas purging.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.