Description

1-Palmitoyl-D31-2-Oleoyl-Sn-Glycero-3-Phosphate (Sodium Salt) is a high-purity, deuterium-labeled phospholipid, specifically a phosphatidic acid (PA) derivative, used as a critical internal standard in quantitative lipidomics and metabolic research. Its value lies in providing unmatched accuracy for mass spectrometry analysis by correcting for matrix effects and ionization efficiency variations. This compound is essential for researchers and quality control laboratories in the pharmaceutical, biotechnology, and academic sectors who require precise quantification of endogenous phosphatidic acid species in complex biological samples.

Application

• Quantitative Lipidomics: Serves as a stable isotope-labeled internal standard for the absolute quantification of phosphatidic acid (PA 16:0/18:1) and related lipids via LC-MS/MS and GC-MS.
• Metabolic Pathway Tracing: Used in deuterium (D) tracer studies to investigate phospholipid biosynthesis, turnover, and signaling dynamics in cell culture and animal models.
• Pharmaceutical R&D: Enables precise pharmacokinetic and biodistribution studies of lipid-based drug formulations and drug-lipid interactions.
• Biomarker Discovery & Validation: Critical for developing and validating clinical assays that measure PA levels as potential biomarkers for metabolic disorders, cancer, or inflammatory diseases.
• Enzyme Activity Assays: Acts as a substrate or product standard in assays for phospholipase D (PLD), lipid kinases, and other enzymes involved in lipid metabolism.
• Quality Control for Diagnostic Kits: Incorporated as a reference material in commercial diagnostic kits and reagents for lipid profiling to ensure assay accuracy and reproducibility.

Basic Information

Product Name	1-Palmitoyl-D31-2-Oleoyl-Sn-Glycero-3-Phosphate (Sodium Salt)
CAS No.	474943-59-4
Molecular Formula	C37H38D31NaO8P
Molecular Weight	~734.0 g/mol (Exact mass available on request)
Synonyms	PA(16:0-d31/18:1(9Z)) Sodium Salt; 1-Hexadecanoyl-d31-2-(9Z-octadecenoyl)-sn-glycero-3-phosphate Sodium Salt; Deuterated POPA Sodium Salt; D31-Palmitoyl-Oleoyl Phosphatidic Acid Sodium Salt; 1-Palmitoyl-d31-2-oleoyl-phosphatidic acid sodium salt; sn-3-Phosphatidic acid, 1-palmitoyl-d31-2-oleoyl-, sodium salt; Lipid Internal Standard PA-d31; [d31]16:0-18:1 PA Sodium Salt
EINECS	Contact for details

Quality Control

Our deuterated phospholipids are produced under strict quality protocols to ensure the high chemical purity and isotopic enrichment required for analytical applications. Each batch is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) is provided, detailing purity, isotopic purity (D-enrichment), and analytical results. We support compliance with ISO 17034 (Reference Material Producer) standards for certified reference materials.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere (argon or nitrogen). Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid or film
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Isotopic Purity (MS)	≥ 98 atom % D
Chemical Purity (TLC)	Single spot
Solubility	Chloroform, Methanol, Chloroform/Methanol mixtures

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.