Description

1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Dodecanyl) (Sodium Salt) is a synthetic, anionic phospholipid derivative, specifically a PEGylated lipid with a dodecanyl (C12) chain, widely recognized for its critical role in advanced formulation science. Its primary value lies in its ability to enhance the stability, circulation time, and targeted delivery of encapsulated active ingredients within complex colloidal systems. This high-purity lipid is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and advanced material science sectors, particularly for developing next-generation nanomedicines and sophisticated drug delivery platforms.

Application

• Lipid Nanoparticle (LNP) Formulation: A key functional excipient for constructing stable, efficacious LNPs used in mRNA vaccines, siRNA therapeutics, and other nucleic acid delivery systems.
• Drug Delivery Vesicles: Incorporated into liposomes and other vesicular carriers to improve payload encapsulation efficiency, serum stability, and pharmacokinetic profiles.
• Biomimetic Membrane Research: Used in model membrane studies to investigate lipid-lipid and lipid-protein interactions due to its unique PEGylated and anionic characteristics.
• Diagnostic Agent Carrier: Serves as a component in the formulation of contrast agents or diagnostic probes for enhanced imaging applications.
• Cosmetic & Dermal Delivery Systems: Employed in high-end cosmetic formulations to create nanocarriers for improved skin penetration and sustained release of active compounds.
• Gene Therapy Vectors: A critical material in the development of non-viral vectors for gene editing and gene therapy applications, facilitating cellular uptake and endosomal escape.

Basic Information

Item	Details
Product Name	1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Dodecanyl) (Sodium Salt)
CAS No.	474923-47-2
Molecular Formula	C77H147NNaO9P
Molecular Weight	~1284.93 g/mol
Synonyms	1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine-N-[dodecanyl(polyethylene glycol)2000] (sodium salt); PEG2000-DSPE; DSPE-PEG(2000)-C12; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[dodecanyl(polyethylene glycol)-2000] (ammonium salt) analog; C12-PEG2000-DSPE; mPEG2000-DSPE (C12); Phospholipid-PEG conjugate; Lipid-PEG-C12
EINECS	Contact for details

Quality Control

Our 1,2-Dioleoyl-Sn-Glycero-3-Phosphoethanolamine-n-(Dodecanyl) (Sodium Salt) is manufactured under strict quality systems suitable for GMP-grade applications. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, NMR for structural verification, and mass spectrometry, to ensure it meets the exacting standards required for pharmaceutical and biomedical research. Comprehensive Certificates of Analysis (COA) with full traceability are provided.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to maintain stability and prevent oxidation and hydrolysis. This product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to avoid condensation.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Assay (Phosphorus Content)	95.0 - 105.0% of theoretical
Water Content (KF)	≤ 3.0%
Residual Solvents (GC)	Meets ICH guidelines
Bacterial Endotoxins	< 10 EU/mg (if applicable)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.