Description

Amg 487 (S-Enantiomer) is a high-purity, single-enantiomer chemical compound, specifically the S-configuration of the potent CXCR3 chemokine receptor antagonist. This compound matters for researchers and developers requiring precise stereochemical control in drug discovery and pharmacological studies. It is primarily needed by the pharmaceutical, biotechnology, and advanced life science research sectors for investigating inflammatory pathways, autoimmune diseases, and oncology targets.

Application

• Pharmaceutical R&D: As a key reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel CXCR3 antagonists.
• Biochemical Research: For in vitro and in vivo studies to elucidate the role of the CXCR3 receptor in T-cell migration and immune response modulation.
• Drug Discovery Screening: Used in high-throughput screening (HTS) assays to identify and validate new therapeutic candidates targeting inflammatory and autoimmune disorders.
• Preclinical Studies: Investigation of pharmacokinetics, metabolism, and efficacy in animal models for conditions like psoriasis, rheumatoid arthritis, and multiple sclerosis.
• Chemical Biology: As a tool compound for studying G-protein coupled receptor (GPCR) signaling pathways and structure-activity relationships (SAR).
• Process Chemistry: Serves as a chiral building block or intermediate in the asymmetric synthesis of more complex therapeutic molecules.

Basic Information

Product Name	Amg 487 (S-Enantiomer)
CAS No.	473720-30-8
Molecular Formula	C₂₀H₂₀N₄O₂
Molecular Weight	348.40 g/mol
Synonyms	NBI-74330; (S)-N-(1-(3-(4-Ethoxyphenyl)-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yl)ethyl)-N-pyridin-3-ylmethyl-2-(4-(trifluoromethoxy)phenyl)acetamide; (S)-AMG 487; CXCR3 Antagonist (S-Enantiomer); S-Enantiomer of AMG-487; 1-[[(3S)-3-[3-(4-ethoxyphenyl)-4-oxopyrido[2,3-d]pyrimidin-2-yl]-3-pyridinyl]methyl]-3-[4-(trifluoromethoxy)phenyl]urea (alternative representation)
EINECS	Contact for details

Quality Control

Our Amg 487 (S-Enantiomer) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC to confirm enantiomeric purity and identity verification by spectroscopic methods. We provide Certificates of Analysis (COA) with detailed results for purity, impurities, and chiral excess, ensuring compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.