Description

Peg-Bib CAS NO 467254-02-0 is a bifunctional polyethylene glycol (PEG) derivative featuring a benzimidazole (Bib) moiety, designed for advanced bioconjugation and cross-linking applications. This compound is valued for its ability to introduce hydrophilic PEG spacers while providing a reactive handle for coupling to biomolecules, thereby enhancing solubility and stability. It is an essential reagent for researchers and manufacturers in the fields of biopharmaceutical development, advanced material science, and diagnostic assay formulation.

Application

• Bioconjugation Linker: Used to covalently attach therapeutic proteins, peptides, or antibodies to other molecules or surfaces, improving pharmacokinetic profiles.
• PEGylation Reagent: Serves as a functionalized PEG spacer for the site-specific modification of biologics to reduce immunogenicity and increase circulatory half-life.
• Polymer Chemistry: Acts as a monomer or cross-linking agent in the synthesis of functionalized hydrogels and smart polymeric materials for drug delivery systems.
• Diagnostic Probe Synthesis: Employed in the development of labeled probes and contrast agents for imaging and biosensing applications.
• Surface Functionalization: Used to modify nanoparticles, chips, or membranes with a hydrophilic, biocompatible PEG layer for reduced non-specific binding.
• Click Chemistry Intermediate: Provides a platform for further functionalization via copper-catalyzed or strain-promoted azide-alkyne cycloaddition (SPAAC) reactions.

Basic Information

Product Name	Peg-Bib
CAS No.	467254-02-0
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Poly(ethylene glycol) Bib derivative; PEG-Benzimidazole; Bifunctional PEG-Bib; mPEG-Bib; Benz-imidazole-PEG; Bib-PEG-NHS ester (if applicable); Bib-PEG-Maleimide (if applicable); Bib-PEG-Azide (if applicable)
EINECS	Contact for details

Quality Control

Our Peg-Bib is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure consistency and compliance with research and cGMP-grade standards where applicable. Comprehensive Certificates of Analysis (COA) detailing purity, functional group assay, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid or viscous liquid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Functional Group Assay	≥ 90%
Water Content (KF)	≤ 1.0%
Molecular Weight (GPC/SEC)	As per ordered specification (e.g., 1kDa, 2kDa, 5kDa)
Endotoxin (LAL)	< 10 EU/mg (for biopharma grades)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.