Description

(4-(2-Fluorophenyl)Piperazinyl)((4-Methylphenyl)Amino)Methane-1-Thione is a specialized organic compound featuring a piperazine core linked to fluorophenyl and tolylamino substituents via a thiocarbonyl bridge. This molecular architecture makes it a valuable advanced pharmaceutical intermediate (API intermediate) and a versatile building block for medicinal chemistry research. It is primarily sought by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel therapeutic agents, particularly within central nervous system (CNS) and receptor-targeted drug discovery programs.

Application

• Pharmaceutical Intermediate: Serves as a critical precursor in the synthesis of potential drug candidates targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used as a key scaffold or building block for structure-activity relationship (SAR) studies and library synthesis in drug discovery.
• Ligand Development: Acts as a core structure for developing ligands targeting serotonin, dopamine, or other G-protein coupled receptors (GPCRs) due to its piperazine moiety.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying enzyme inhibition or receptor binding mechanisms.
• Fine Chemical Synthesis: Employed in custom synthesis and contract manufacturing for producing high-value, low-volume specialty chemicals.

Basic Information

Product Name	(4-(2-Fluorophenyl)Piperazinyl)((4-Methylphenyl)Amino)Methane-1-Thione
CAS No.	460993-12-8
Molecular Formula	C18H20FN3S
Molecular Weight	329.44 g/mol
Synonyms	1-[(2-Fluorophenyl)piperazin-1-yl]-N-(4-methylphenyl)methanimidothioic acid; N-(4-Methylphenyl)-1-[4-(2-fluorophenyl)piperazin-1-yl]methanimidothioic acid; 460993-12-8; (4-(2-Fluorophenyl)piperazin-1-yl)(p-tolylimino)methanethione; Thiourea, N-(4-methylphenyl)-N'-[4-(2-fluorophenyl)-1-piperazinyl]-(9CI)
EINECS	Contact for details

Quality Control

Our production of (4-(2-Fluorophenyl)Piperazinyl)((4-Methylphenyl)Amino)Methane-1-Thione adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Every batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), related substances, and physical properties are provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under anhydrous conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.