Description

tert-Butyl 4-[(2-Bromo-4-Fluorophenyl)Methyl]Piperazine-1-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a piperazine core with bromo and fluoro substituents. This compound matters for its critical role as a versatile building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and oncology research. Pharmaceutical manufacturers, contract research organizations (CROs), and fine chemical suppliers need this material for developing new drug candidates and scaling up production processes.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting neurological disorders and cancer.
• API Synthesis: Used in the multi-step synthesis of complex Active Pharmaceutical Ingredients (APIs) requiring a functionalized piperazine moiety.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery.
• Chemical Reference Standard: Employed as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical laboratories.
• Custom Synthesis: A starting material for the custom synthesis of more complex, target-specific molecules for preclinical and clinical development.

Basic Information

Item	Details
Product Name	tert-Butyl 4-[(2-Bromo-4-Fluorophenyl)Methyl]Piperazine-1-Carboxylate
CAS No.	460094-96-6
Molecular Formula	C16H22BrFN2O2
Molecular Weight	373.26 g/mol
Synonyms	1-Boc-4-[(2-Bromo-4-fluorobenzyl)]piperazine; 4-[(2-Bromo-4-fluorophenyl)methyl]-1-piperazinecarboxylic acid 1,1-dimethylethyl ester; tert-Butyl 4-(2-bromo-4-fluorobenzyl)piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-(2-bromo-4-fluorobenzyl)piperazine; Boc-4-(2-bromo-4-fluorobenzyl)piperazine; 460094-96-6
EINECS	Contact for details

Quality Control

Our tert-Butyl 4-[(2-Bromo-4-Fluorophenyl)Methyl]Piperazine-1-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring material suitable for use in regulated pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to prevent exposure to atmospheric moisture, which can affect purity and stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.