Description

Hydroxy-Peg2-Methyl Ester is a versatile bifunctional polyethylene glycol (PEG) derivative, serving as a crucial building block in advanced organic synthesis and bioconjugation. Its value lies in providing a hydrophilic spacer arm with a terminal hydroxyl group for further functionalization and a methyl ester for efficient coupling reactions. This compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and material science industries who require high-purity linkers for developing prodrugs, polymer therapeutics, and functionalized surfaces.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of antibody-drug conjugates (ADCs), prodrugs, and targeted drug delivery systems.
• Bioconjugation & PEGylation: Used to introduce hydrophilic PEG spacers onto peptides, proteins, or small molecules to improve solubility, stability, and pharmacokinetic profiles.
• Polymer Chemistry: Serves as a monomer or cross-linker for creating functionalized, biodegradable, or stimuli-responsive hydrogels and polymers.
• Surface Modification: Employed to functionalize nanoparticles, quantum dots, or diagnostic assay surfaces with hydrophilic, biocompatible layers.
• Chemical Probes & Reagents: Utilized in the development of fluorescent dyes, affinity labels, and other research reagents requiring a defined linker chemistry.
• Cosmetic & Personal Care Ingredients: Intermediate for synthesizing PEG-based emulsifiers, surfactants, and delivery agents in advanced formulations.

Basic Information

Product Name	Hydroxy-Peg2-Methyl Ester
CAS No.	457897-73-3
Molecular Formula	C7H14O5
Molecular Weight	178.18 g/mol
Synonyms	2-[2-(2-Hydroxyethoxy)ethoxy]acetic acid methyl ester; Methyl 2,5,8-trioxaundecanoate; 3,6-Dioxaoctanoic acid, 8-hydroxy-, methyl ester; HO-PEG2-CH2COOCH3; PEG2 methyl ester alcohol; 8-Hydroxy-3,6-dioxaoctanoic acid methyl ester; 2-(2-(2-Hydroxyethoxy)ethoxy)ethyl methyl ester; Ethanol, 2,2'-[1-(methoxycarbonyl)methoxy]di-
EINECS	Contact for details

Quality Control

Our Hydroxy-Peg2-Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and consistent performance. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at 2-8°C or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under dry, inert conditions to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.