Description

(S)-Ethyl 3-(4-(2,7-Naphthyridin-1-Ylamino)Phenyl)-2-(2-Bromo-3-Oxospiro[3.5]Non-1-En-1-Ylamino)Propanoate is a high-purity, advanced pharmaceutical intermediate featuring a complex molecular architecture with a chiral center and a spirocyclic moiety. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new drug candidates, particularly in oncology and other disease areas requiring sophisticated small-molecule modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for novel drug discovery programs.
• Protease Inhibitor Synthesis: Serves as a precursor in the synthesis of potential enzyme inhibitors due to its complex, functionalized structure.
• Kinase Inhibitor Development: Employed in the construction of candidate molecules targeting various kinase pathways relevant in cancer and inflammatory diseases.
• Chemical Biology Probes: Utilized to create specialized molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Supplied for route scouting and optimization from milligram to kilogram scale for clinical trial material production.

Basic Information

Item	Details
Product Name	(S)-Ethyl 3-(4-(2,7-Naphthyridin-1-Ylamino)Phenyl)-2-(2-Bromo-3-Oxospiro[3.5]Non-1-En-1-Ylamino)Propanoate
CAS No.	455264-30-9
Molecular Formula	C30H30BrN5O3
Molecular Weight	588.50 g/mol
Synonyms	Ethyl (S)-3-[4-[(2,7-naphthyridin-1-yl)amino]phenyl]-2-[(2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino]propanoate; (S)-Ethyl 3-(4-(2,7-Naphthyridin-1-ylamino)phenyl)-2-((2-bromo-3-oxospiro[3.5]non-1-en-1-yl)amino)propanoate; 455264-30-9; UNII-Contact for details; Spirocyclic Naphthyridine Derivative; Bromo-spiro[3.5]nonene Propanoate Ester
EINECS	Contact for details

Quality Control

Our (S)-Ethyl 3-(4-(2,7-Naphthyridin-1-Ylamino)Phenyl)-2-(2-Bromo-3-Oxospiro[3.5]Non-1-En-1-Ylamino)Propanoate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling by HPLC, to ensure compliance with exacting research and development standards. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and consistency for your critical projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.