Description

Piperazine, 1-(Chlorodifluoroacetyl)-4-Hydroxy- (9Ci) is a specialized piperazine derivative featuring a chlorodifluoroacetyl functional group. This compound is a valuable high-purity synthetic intermediate for constructing complex molecules in advanced chemical synthesis. It is primarily utilized by pharmaceutical R&D and fine chemical manufacturers for the development of novel active ingredients and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds requiring a functionalized piperazine core.
• Agrochemical Research: Used in the development of new crop protection agents and herbicides, leveraging its unique halogenated structure.
• Material Science: Serves as a precursor for specialty polymers, ligands, or advanced organic frameworks with tailored properties.
• Chemical Synthesis: Employed in medicinal chemistry for lead optimization and structure-activity relationship (SAR) studies.
• Fluorochemical Production: Acts as a versatile intermediate for introducing the chlorodifluoroacetyl moiety into target molecules.

Basic Information

Product Name	Piperazine, 1-(Chlorodifluoroacetyl)-4-Hydroxy- (9Ci)
CAS No.	453557-83-0
Molecular Formula	C7H9ClF2N2O2
Molecular Weight	226.61 g/mol
Synonyms	1-(Chlorodifluoroacetyl)-4-hydroxypiperazine; 4-Hydroxy-1-(chlorodifluoroacetyl)piperazine; N-(Chlorodifluoroacetyl)-4-hydroxypiperazine; 1-(2-Chloro-2,2-difluoroacetyl)-4-hydroxypiperazine; Piperazine, 1-(chlorodifluoroacetyl)-4-hydroxy-; 453557-83-0; 1-(Chlorodifluoroacetyl)piperazin-4-ol
EINECS	Contact for details

Quality Control

Our Piperazine, 1-(Chlorodifluoroacetyl)-4-Hydroxy- (9Ci) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if necessary.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.