Description

1,1,1-Trifluoro-3-[4-(2-Fluorophenyl)Piperazino]-2-Propanol is a high-purity fluorinated piperazine derivative, a key advanced pharmaceutical intermediate (API) in modern medicinal chemistry. Its value lies in its unique trifluoromethyl and fluorophenyl motifs, which are critical for enhancing the metabolic stability, bioavailability, and binding affinity of target drug molecules. This compound is essential for research and development chemists in the pharmaceutical industry, particularly those focused on synthesizing novel central nervous system (CNS) agents, antipsychotics, and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical building block for the synthesis of novel psychotropic and neuroactive drug candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to optimize lead compounds, leveraging the fluorine atoms for improved pharmacokinetic properties.
• CNS Drug Development: A key precursor in the research and production of potential antipsychotic, antidepressant, and anxiolytic agents.
• Biochemical Tool Compound: Employed in pharmacological research as a reference standard or probe to study specific receptor interactions.
• Custom Synthesis: Used by contract research and manufacturing organizations (CROs/CMOs) for the bespoke synthesis of complex fluorinated molecules for clients.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis projects and the development of new fluorination methodologies.

Basic Information

Product Name	1,1,1-Trifluoro-3-[4-(2-Fluorophenyl)Piperazino]-2-Propanol
CAS No.	453557-80-7
Molecular Formula	C13H16F4N2O
Molecular Weight	292.27 g/mol
Synonyms	1,1,1-Trifluoro-3-[4-(2-fluorophenyl)-1-piperazinyl]-2-propanol; 3-[4-(2-Fluorophenyl)piperazin-1-yl]-1,1,1-trifluoropropan-2-ol; 2-Propanol, 1,1,1-trifluoro-3-[4-(2-fluorophenyl)-1-piperazinyl]-; TFPP; (RS)-1,1,1-Trifluoro-3-[4-(2-fluorophenyl)piperazino]-2-propanol
EINECS	Contact for details

Quality Control

Our 1,1,1-Trifluoro-3-[4-(2-Fluorophenyl)Piperazino]-2-Propanol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliability for research and development use.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere if specified. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.